Author: ayslblog

Consequently, the typical drug model, active principle(s) in multicomponent herbal medicines, cannot be applied to anything but synthetic drugs.  The notion that coffee is caffeine held by some drug scientists a generation or two ago is no longer possible.  But many of my drug-trained colleagues still hold onto the concept of an active principle in multiple-component herbs, unaware of, or ignoring other more important, also active, chemicals present.  Some still practice it, leading to repeated false or irrelevant results.  Seriously, how much of our published psychedelics research in the past century  was due to uncertain identity or impurities containing highly active compounds (like LSD in psilocybin for whatever reason)? 

For above reasons, I don’t consider our modern synthetic drug therapy scientific.  Nor is it based on human experience and accumulated wisdom, as with traditional medicines   Regardless, both therapies have merits despite their deficiencies.   Which is why I have been advocating the use of both, but with prudence.   

In my last post, I mentioned using both synthetic drug therapy and tried-and-true traditional medicines in treating our illnesses.  That is only when we have no other alternatives like it is now, when we have available only synthetic drugs along with the vicious cycle (VC) they cause that in turn leads to unavoidable side effects and new diseases.   They can be ameliorated by traditional medicines if available.  However, the best alternative is to avoid or bypass using synthetics altogether.   Now is as good time as any other to start for the following reason. 

Since the synthetic drug era began about 150 years ago, we have been making both ingestible chemicals (as drugs & additives) and non-ingestible chemicals (for our  convenience & pleasure) nonstop and ongoing.  They must be hundreds of thousands, or millions, in number by now.  Who knows what their tonnage is, and will be, a few decades from now.   Since over 50 years ago, I already had succeeded in growing  a totally natural magic mushroom mycelium (Psilocybe baeocystis) containing PBN (psilocybin baeocystin norbaeocystin), the closest analogs to serotonin (a hormone and neurotransmitter throughout our body which we might have studied closely and have invented specializations of which we are so proud.  What exactly do or can these closest analogs do to our mental and physical health other than making them rest at serotonin ‘receptors’ (whatever and wherever they are).   It has been over half a century since my discovery of 2 of these closest analogs to serotonin, no scientists have even succeeded in repeating my work despite it has been published in 4 detailed papers.  When I rejoined the psychedelics movement about 5 years ago, on reviewing my work, I discovered we can actually rinse/wash my fungal mycelium with distilled water, dry it, and we would have a totally natural psychedelic product.  No extraction with solvents or reagents is necessary.  Hence, no contaminants from synthetic chemicals such as from biotech, enzymatic, or other technologies eventually will require extraction of the chemicals from mixtures of culture fluids.           

More on the VC  in my  next post.  So, until then!

Since the VC is the origin of the major health problems in our country, I will spend the next few posts rehashing this issue and its closely interrelated problems that I have been describing for years in my posts and books.

Synthetic drugs and additives have one thing in common.  They are all made from toxic petroleum or other fossil fuels.  Hence, they are inherently toxic.  Our recent forebears were smart and correct in designing scientific tests (in vitro, in vivo, small creatures, etc.) to be sure they are effective, or at least safe, before subjecting them to clinical trials in humans, then after approval, release them for patient use.  This last step is the same trial-and-error process our ancient ancestors used when they were developing our traditional medicines eons ago.  This process of our traditional medicines has lasted not just decades but millennia or countless years when we inherited traditional medicines from our ancestors.  In contrast, our modern synthetic drugs have gone through scientific treatment, tops a few years, and we consider them safe and effective (but in ‘animal’ lifetimes) and try them in humans.  Even though our human lifetime is only 60 to 80 years, some of the toxic effects of synthetic chemicals may only start to appear, hardly proving that they are safe and effective. 

For above reasons, I don’t consider our modern drug therapy scientific.  Nor are they based on human experience and accumulated wisdom.   Regardless, both therapies have merits despite their deficiencies.  Which is why I have been advocating the use of both but with prudence.  More on the VC  in my next post.  So, until then!

Wrong identity or impure test materials can mean unreliable or misleading results.  Remember what the basis was for the so-called ‘ginseng-abase syndrome’?  Something labeled ‘ginseng’ from a  store!?   Or the MD declaring he could do acupuncture because he was used to  sticking needles in patients.

Now closer to home (our psychedelics) – just consider 1% LSD present in a dose of psilocybin for whatever reason; that would double the psychedelic effects because LSD is up to 200X stronger than psilocybin.  So, my colleagues, be careful!   Has any of our colleagues published research that shows this purity/identity issue of any commonly used or researched synthetic psychedelic, one way or another?

In the next post, I want to continue to connect the vicious cycle (VC) of drug therapy using synthetic chemicals with the persistent poor health of Americans, exploited or caused by the drug industry.   The only way to eliminate this VC is by government-owned healthcare as most truly democratic, educated, or civilized nations like Canada and the Scandinavian countries, whose multibillionaires pay taxes unlike ours who don’t pay any.

The latter were produced mainly for our pleasure and convenience which over time in mere decades have degraded into minute entities.  These enter our body through our drinking water and adding to the damage done to our body by our ingestible drugs and additives (plus the new microplastics).  One thing most of us overlook is that these inherently toxic synthetic drugs and additives made from toxic petroleum don’t show their toxic effects in a day or two, or even a month. 

Unlike our traditional medicines that are time-tested for years, centuries, or millennia, synthetics show their ugly face in decades, shortening our lives or making us barely able to walk or think clearly even in our fifties or sixties.

Now the vicious cycle (VC) that I have been describing all these years is not just caused by ingestible synthetic drugs and additives but also by these pollutants in our environment due to degrading synthetics.  So far, except for some very minor attention starting to pay to these pollutants, the whole field of synthetics is still flourishing and unstoppable.  I have no idea whether any of our world nations are doing anything about them.  Regardless, whatever they do, in my opinion, is not enough to slow down any of these synthetics, either edible or inedible.   As world citizens, we have to do our part to make our fellow humans safer and healthier.   I have been trying to bypass at least some of the synthetics, but I haven’t found a computer/business partner.  The ones I have bumped into so far are money chasers with whom I have nothing in common.  So, I will keep on writing!   Because I am a perpetual optimist…   

I can’t imagine having to continue to take the toxic synthetic drugs for another 40 years!  I would have been long gone and no longer writing, or fast-walking 20 to 25 miles a week at my age, a young 88. 

Coming from tropical Hong Kong to Ann Arbor, Michigan, for graduate studies in 1962, I developed hay fever within 3 years.  The attending physician in the student’s health service took one look at me and extended to me his greeting, “Welcome to hay fever town!”  Since then, I had to take all kinds of drugs (antihistamines, nasal decongestants, etc.) for at least 20 years and suffered through all the side effects.  

Then, between the 1^st edition (1980) and 2^nd edition (1996) of my Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics (Wiley), I was seriously involved in building a library of Chinese herbal medicines while growing my business to include a manufacturing facility and a lab.   By around 2000 my library had probably the best and the most extensive collection of traditional Chinese herbal books and journals in America in a single location.  That was when my company, Phyto-Technologies, won a SBIR research grant for $1.5M.  All the above information is recorded in the memoir part of my last book, My Life & Rollercoaster Career (CreateSpace/Amason, 2018).  

After over 20 years of taking synthetic drugs for months yearly, the magnolia flower buds got rid of my hay fever.   No more synthetic drugs for my hay fever or runny nose since around mid 1980s.  Now, whenever it  strikes me, maybe once to a few times yearly, xinyi always works.  So far this year, a couple of weeks ago it struck me again.  But all I  did was to take 1 dose of xinyi (2-3 tablespoons of crushed buds in a cup, filling it ¾ full with boiling water, let stand for ~10 min & screened off the fuzz).  Yesterday, it was a bad one, I sneezed not long after getting up in the morning and my nose was dripping.  As I needed to go out and I didn’t want to keep blowing and wiping my nose.  So, I took a dose 30 minutes before I went out.  The sneezing and dripping stopped in 10 to 15 minutes.  I was able to interact with others with not much inconvenience.  When I came home 4 hours later, I didn’t want to use a handkerchief anymore that day, so I took another dose.  I slept with no problems last night.  It’s now early evening; my hay fever is no longer there. 

Here, I want to make one point about natural medicines.  Unlike synthetics, we have tried unsuccessfully to make using them precisely scientific at least for a short time, like the past 8 decades.  We still have to depend on the trial-and-error experience just as our ancestors.  These synthetic drugs would have disappeared decades or a century ago if not for the vicious cycle (VC) they continue to cause.  By now, if you have not heard of the VC, you are either asleep, a synthetic drug maker and peddler, or an interdependent associate (insurance agent, advertiser, promotor, or crooked politician).  Please ponder it!  Our poor health is mostly caused by synthetic chemicals (drugs & additives).

We need both!   Synthetics have caused countless side effects and new diseases while herbal medicines need intensive efforts to preserve before they disappear in the healthcare world run by ignorant or arrogant scientists educated and trained by Big Pharma, some are greedy.

We have tried to make the former scientific, but we don’t have the means to make it so, in our complex body full of countless  entities like tissues, cells, and cell contents, especially chemicals.  We are still struggling to make them comply with some manmade rules for its cellular (in vitro & in vivo) and small -animal entities.  But after approval of our human clinical-trial step, we still must do exactly as our ancestors had done, subjecting patients to the trial-and-error process.  We have been doing this over the past 8 decades, or more.  Yet we have not learned our lessons. 

The most  obvious and notorious recent ones include Thalidomide in the 1950s/1960s when pregnant patients who consumed it later gave birth to seriously deformed babies (some without arms or legs).  The more recent example within the past decade is Ingrezza (valbenazine)  used in treating tardive dyskinesia that is caused by antipsychotic and gastrointestinal drugs.  This is a typical case that belongs to the synthetic drug-therapy’s vicious cycle (VC).  Just wait for another decade or two and see what  side effects and new diseases Ingrezza will cause.  When it was approved by the FDA in 2017, I was so naïve as to wait for the drug industry to finally recognize the VC as I had described it and start doing something to discontinue (or at least avoid) synthetic drug use.  Instead, this toxic synthetic drug became the star money maker, approved by our FDA.

The discovery of my totally natural Psilocybe baeocystis fungal mycelium for a new safer and less toxic therapy was a serendipity.  It occurred around 2020, over fifty years after my advisor/mentor and I published my graduate research detailing my isolation of the two new psilocybin analogs we named baeocystin and norbaeocystin in 1968.  From 1968 to around 2020, over half-a-century, I did not have anything to do with magic mushrooms.    Regardless, I spent two-and-a-half years doing postdoctoral work with Professor Einar Brochmann-Hanssen in the biosynthesis of opium alkaloids and was co-author in five published papers.  Then, I was employed and fired by two companies for a total of five-and-a-half years before I became an independent consultant for fifty years.

Around 2019–2020, I decided to promote my new book online, My Life & Rollercoaster Career. Published by CreateSpace/Amazon in late 2018, it combines my memoir with eight years of newsletters (1996–2004) in a single volume. The memoir covers my family, education, life in Hong Kong, Taiwan, and the United States, and personal challenges such as inattention and possible ADHD. The newsletter reprints my career experiences, first published monthly, then bimonthly, and later quarterly. I eventually stopped because of my consulting schedule, grant work, and travel. In those newsletters, I discussed both synthetic drug therapy and traditional medicine. Although the two are very different, each has strengths as well as limitations. Used together, their strengths and weaknesses can complement one another.

After I returned from retirement to join LinkedIn to promote my book, within weeks I noticed chatters on psilocybin and magic mushrooms.   I rejoined the psychedelic movement and basically forgot about my book promotion. I have then noticed that many businessmen treat their endeavors as if they were ‘goldrush’ adventures.  They also don’t distinguish between natural therapy and synthetic therapy, claiming the former scientific but unaware of the experience and wisdom of the latter.  After working with a few such groups, I decided to form our PBN Naturals Worldwide Consortium to produce natural PBN mycelia cooperatively so as not to gouge or exploit others less fortunate.  

It was only then, when reviewing my long-neglected PBN work, that I realized one of the steps in my routine extraction of the Ps. baeocystis mycelia for isolating psilocybin and analogs involved a rinsing step with clean distilled water before drying the mycelial pellets for extraction.  I never paid attention to this step at the time.  But now, that simple step is the key to our commercial totally natural PBN mycelia with no synthetic contaminants like chemicals produced by synthetic, enzymatic, and biotech processes.  That is the principle I use for our organization – PBN Naturals Worldwide Consortium.  Together, we can produce totally natural mycelia containing pure PBN!  This technique can be applied to other natural products, especially unregulated herbal supplements where two products from two different companies, with identical herbal ingredients on their labels, can be as different as night and day!  The industry is full of products like these.  Join our Consortium if you want to help us change things. 

Over my 60-year professional career, I have written about drugs and herbs in articles, newsletters, books, and online posts. During graduate school, I worked on liquid cultures of Psilocybe mycelia and isolated two new compounds closely related to both psilocybin and serotonin, which I named baeocystin and norbaeocystin. After that, I was not involved with psychedelic mushrooms for about 53 years. In 2020, when I rejoined LinkedIn to promote my book My Life & Rollercoaster Career (2018, CreateSpace/Amazon), I noticed extensive online discussions about psilocybin and other psychedelics. Within weeks, I had reentered the psychedelic movement.  My book was promptly forgotten. 

Within months, I began to see the movement as a kind of gold rush, led in part by greedy selfish businesspeople who were second- or third-tier leaders but considered themselves technical experts. After I distanced myself from them, they either collapsed or faded from view. I had seen this pattern several times during my long consulting career.  I think my undiagnosed ADHD might have something to do with it because my inattention when dealing with their technical ignorance and arrogance might have shown myself to be dumb to them.  

The fact remains that no one has produced fungal mycelia containing PBN since I first published it in 1968, more than half a century ago. To date, PBN-related materials have been only synthesized or produced through biotechnology or enzyme conversion. All of these methods require extraction and may introduce synthetic impurities. As a result, they remain within the vicious cycle (VC) of drug therapy and do not eliminate the risk of using test materials with the wrong or uncertain identity in research problems that have generated a great deal of unreliable data. As I discussed in the five key issues in my June 9, 2026, post, which few of my scientific colleagues have addressed, more published studies based on uncertain or incorrect test materials are likely to continue. Examples include treating caffeine as coffee, curcumin as turmeric, or citing the notorious “ginseng abuse syndrome” paper as though it accurately represented ginseng, along with many other cases of misidentified herbs.

We can’t continue to let the VC and a handful of narcissistic gazillionaires holding the world’s wealth hence the power, dictate the direction of our health and fate.  With my approach, at least starting with totally naturals (fungal mycelia containing natural PBN), we can start to bypass the VC that has controlled our research focus and health for so many decades!  More on our PBN Naturals Worldwide Consortium in my next post.  So, stay tuned!

My June 10, 2026, post – based on item #5 in my last post (June 9, 2026) – clearly shows that our synthetic drug therapy has a lot lacking. 

I have observed this for a long time and have been pointing it out, but no colleagues seemed to dare openly agree with me for various reasons.

Since the science in our drug therapy is based on an active synthetic chemical that is brand new to our plant and most likely inherently toxic because it is produced from toxic petroleum.  Our complex multichemical body has never been in contact with it since our human species appeared o earth eons ago.  Some chemicals among the millions or billions within our body are bound to reject this new stranger.  Hence, the toxic side-effects and/or new diseases with our new synthetic drugs.   If the therapeutic entity is a natural chemical or herb containing many chemicals, like the chemicals in our body, they all have had prior contact and interactions with one another.  Hence, no vicious cycle will be created.  Unless someone decided to try petroleum on his headache or aching joints using the trial-and-error process our ancient ancestors had used.  See how long he would survive to tell his story.

Nevertheless, active-chemical-based drug therapy has its weak points.  It is only scientific maybe up to its human clinical-trial step.  After its approval for patient use, it is the trial-and-error process our ancestors had used for developing our traditional medicines.  However, the synthetic drug’s toxic nature may not show up for months, years, or decades.  And the time element in modern drug therapy is lacking!

Therefore, the deficiencies of modern active-chemical(s)-based therapy using synthetic drugs and those of traditional medicines can be used complementarily.  We can then take advantage of their good points along with their deficiencies.  We just have to mind the pluses of each but be always aware of their un-miscible elements.   I know how to start to restore our rapidly declining health by bypassing the vicious cycle caused by using synthetic drugs in therapy and way too many additives in our foods and drinks.  We can start this by targeting natural psychedelics, first using  totally natural Psilocybe mycelia containing PBN.  Some of the issues that I raised in at least the #5 item in my last post should no longer be major problems when dealing with synthetic chemicals.

1. Compared to traditional medicines used by us for thousands of years, synthetics have only 150 years of human use history – a tiny fraction.  However, being made from toxic petroleum, they are inherently toxic and the scientific tests (in vitro, in vivo, in small animals, etc.) are meant to see how toxic they are before subjecting them to clinical trials in humans;
2. Petrochemicals are not the same as plant and animal substances our ancestors tested over countless generations to learn what was edible or medicinal. Many of them people died during that process. Yet some argue that because petroleum is natural, chemicals derived from it are therefore not toxic. I am not aware of any ancestral tradition based on people safely consuming petroleum and passing down that experience.
3. Few, if any, of us have also addressed the issue of purity of synthetic drugs.  World pharmacopoeias usually list up to a few %.  But even 1% of an impurity in synthetics can spell serious trouble if that chemical is particularly strong-acting or highly toxic.  For example, if 1% of LSD is added to psilocybin, a normal dose of the latter containing the LSD would make its psychedelic effects double because LSD is up to 200x stronger acting than psilocybin.  Regardless, how many studies of synthetic psilocybin over the past 25 years had unknown strong-acting or toxic impurities therein without the researchers’ knowledge?  These would  have obviously distorted our research data.  How much of our research literature over the past several decades was based on unsure test objects (drugs), meaning useless resulting data?    Plenty! Because I have encountered this quite often myself. 
4. Antibiotics (penicillin), steroids (testosterone & cortisone), and opioids (morphine, heroin & fentanyl) are some of the most useful and then abused drugs we have.  The fields have turned from a few life savers to increasingly more new drugs being abused along with new diseases that require more new drugs to treat, thus perpetuating the vicious cycle (VC).   And treating drug abuse is itself a booming industry!  
5. No one mentions that our modern drug-therapy process with synthetics is not scientific.  Its initial testing on in vitro and in vivo cell systems is scientific, so may be in animals with limited life span (whose results cannot be directly translated to humans).  Then, when clinical trials are done on humans for increasingly shorter time before approval, we still have to go through the trial-and-error process in patients – the same process used by our ancient ancestors thousands of years ago.  So, our modern drug development and testing process is not complete (lacking science and/or human wisdom) without using the trial-and-error step along with its essential time element – millennia, not just a generation or two.