As I have repeatedly explained, natural chemicals don’t have the same kind of toxic impurities synthetic ones have. Like those in foods, we already know them to be safe to ingest. Hence, if we have an herbal extract containing 75% of a chemical we seek, we could just use the mixture in therapy. Remember, many of our natural medicines are foods and should be treated as such and not as pharmaceuticals, especially using inappropriate technologies. Our zeroing in on any arbitrary phytochemical and forcing it to meet drug standards has served Big Pharma well. It has facilitated and encouraged the use of synthetics, thus created the vicious cycle. That’s why over the past decades, we have been unable to validate the benefits of any natural medicines. Yet, due to arrogance or ignorance and, above all, GREED, we’ve declared them unscientific and about to relegate a healing system with millennia of human clinical experience, to historical museums. Let’s NOT let this happen to our psilocybin, baeocystin & norbaeocystin. hashtag#naturalhashtag#synthetichashtag#psilocybinhashtag#baeocystinhashtag#norbaeocystinhashtag#impuritieshashtag#foodhashtag#herbhashtag#toxichashtag#medicinehashtag#pharmaceuticalshashtag#phytochemicalhashtag#BigPharmahashtag#viciouscyclehashtag#arrogancehashtag#greed
Natural vs. synthetic: 1. An issue for my colleagues to seriously consider.
Say we have a new chemical freshly synthesized from a reaction mixture, and it only makes up 75% of the mix. The rest is mostly unknown intermediates & byproducts from petrochemicals. We can’t just take it and adjust the drug’s dose to treat patients, because we know there are all these potentially very toxic chemicals in it. They must be removed by a purification process. However, after 80 plus years of continuous efforts by scientists trying to develop new or improved drugs, our efforts have led us to the vicious cycle. The major mistake we have made is the failure to understand the damage these impurities in synthetic drugs can do to patients who take them. Once we are in our v.c., the monetary incentive to maintain the status quo would be too strong for Big Pharma & Associates to do anything about. My next post will address the same mistake applied to psilocybin, baeocystin & norbaeocystin and its ramifications. hashtag#natural hashtag#synthetic hashtag#purity hashtag#petrochemicals hashtag#impurities hashtag#toxic hashtag#byproducts hashtag#viciouscycle hashtag#psilocybin hashtag#baeocystin hashtag#norbaeocystin hashtag#drugs hashtag#BigPharma hashtag#statusquo hashtag#monetaryincentive
My personal message to colleagues and acquaintances:
Please don’t feel offended if I haven’t responded to most of your questions regarding what I have done and can do. For those of you who know me, or at least have read my personal story, I think you already understand my handicaps. Frankly, I no longer have companies to run or competent assistants to help me with all sorts of paper work. Now I am just one old dude and spend most of my time in technical matters, and there are quite a few. Only in recent weeks I have added my long-neglected ‘babies’- baeocystin & norbaeocystin as well as psilocybin. I see immense potential of these in relieving the ills our overstressed society has caused us, along with its vicious cycle established by normal ‘modern’ drug therapy. Whatever I’ll do in collaboration with my like-minded scientists and friends with psilocybin mushrooms will be openly shared around the world so as to prevent any one group to exploit the sick and poor or shut out competition to keep enriching themselves to become billionaires and gazillionaires… hashtag#handicaps hashtag#baeocystin hashtag#norbaeocystin hashtag#psilocybin #hashtag#viciouscycle hashtag#stress hashtag#drugtherapy hashtag#mushrooms hashtag#exploitsick&poor hashtag#competition hashtag#billionaire hashtag#gazillionaire
I believe in fate. You’ll see what I mean if you read my newest book.
Normally, I wouldn’t have graduated from high school, or gotten a college degree. Then, with a mere B average, I was offered a teaching assistantship to go to Michigan to pursue graduate studies. There, I was assigned the project of growing Psilocybe baeocystis in liquid culture. I succeeded in inducing it to produce enough of the psilocybin analogs which I isolated, identified, and named baeocystin and norbaeocystin. That was from 1962 to 1967. Twenty or 30 years of minimal activities followed, though I remember having read about my new compounds being detected in other related fungi, verifying my work. Then, only in the last 2 months was I aware of the flurries of news and activities in psilocybin mushrooms. I quickly realized no one had access to these psilocybin analogs for further research. So only a couple of weeks ago I decided to produce these by fermentation. And here I am, ready to work with only non-greedy individuals. If you are one of those exploiters of human health and miseries, don’t contact me. Otherwise, please do! Sorry for being so blunt. hashtag#fate hashtag#Psilocybebaeocystis hashtag#psilocybin hashtag#baeocystin hashtag#norbaeocystin hashtag#mushrooms hashtag#production hashtag#fermentation hashtag#health hashtag#miseries hashtag#analogs
PATENTS! Should they be part of healthcare?
I think NOT, as they can adversely affect people’s finances (medicine, food, or shelter) and their health (life or death). They allow a greedy drug maker to prevent others from producing the same drug whether or not it works, thus freely gouging consumers at profits 50X, or even 500X over their costs. They do this apparently without the slightest concern for some of our compatriots who are too poor to afford the drug. As dedicated scientists, we may never think of this. But the people who control the vicious cycle of drug therapy (our big bosses) would not hesitate to prey on the sick with their attendant miseries to enrich themselves. In a recent post, I wondered that our yearly healthcare costs might be in $trillions instead of $billions. Is anyone keeping track of them? With the approval of Valbenazine (Ingrezza), the v.c. was firmly established, providing a perpetual one-way flow of money from us to Big Pharma but offering us no substantial returns. Instead, more drug-caused diseases which require more new drugs to treat, perpetuating the v.c.! Where are our senators, congressmen, and president, who supposedly serve our interests? hashtag#patentshashtag#costshashtag#healthcarehashtag#gouginghashtag#profitshashtag#viciouscyclehashtag#drugtherapyhashtag#Ingrezzahashtag#senatehashtag#congress
¿Un negocio debería beneficiarse de nuestra salud?
La terapia de drogas orientada a los beneficios le ha hecho daño a nuestro país, dando nos su ciclo vicioso. La salud no debe ser parte de esto. Si lo es, debe ser propiedad de los consumidores, los ciudadanos o sin fines de lucro. Necesitamos renovar todo el sistema de salud, especialmente, la terapia de drogas. Creo que nuestras generaciones más jóvenes, siendo más conscientes de nuestro deterioro de la salud general, iniciarían el proceso. Para evitar quedarse atascado con el ciclo vicioso unilateral, no tienen otra opción que tomar la ruta no sintética, porque después de 80 años de ejercicios sintéticos sin verdaderos beneficios para nuestra salud general, necesitamos un descanso de vuelta a la naturaleza. ¡Lo hemos encontrado en setas de psilocibina! Voy a pasar el resto de mi vida para asegurarnos de que esto no conduce de nuevo a los sintéticos como con los suplementos herbales. En su lugar, la psilocibina, la baeocistina y la norbaeocistina se producirán por fermentación y se estandarizarán in situ para la investigación y el tratamiento de enfermedades importantes. hashtag#saludhashtag#terapiahashtag#cicloviciosohashtag#drogashashtag#sintéticoshashtag#cicloviciosohashtag#naturalhashtag#psilocibinahashtag#baeocistinahashtag#norbaeocistinahashtag#fermentaciónhashtag#enfermedadhashtag#investigación
For decades I have been pondering healthcare as a business in a free country. Should anyone profit from it?
Look what profit-oriented drug therapy has done to our country – its well-established vicious cycle only benefits drug-makers and their associates.
Our precious health should not be traded or sold at will. If it is turned into a business, it should be either non-profit or consumer(patient)-owned. Otherwise, it should be run by our government after its REAL ‘swarm’ has been drained.
The whole healthcare system, esp., drug therapy, has to be revamped. I believe our younger generations with their increasingly non-drug and true-prevention approach, would start the process. And to avoid being stuck with the one-sided vicious cycle, they have no choice but to take the non-synthetic route because after 80 years of synthetic exercises without true benefits to our overall health (despite some isolated advances), we need the break back to nature. We have found it in psilocybin mushrooms! I will spend the rest of my life to ensure this does not again lead to synthetics as with herbal supplements. Instead, psilocybin, baeocystin, and norbaeocystin will be produced by fermentation and standardized in situ for research and treatment of major diseases. #healthcare #business #nonprofit #consumer patientowned #government #psilocybin #baeocystin #norbaeocystin #drugtherapy #alternative
Los costos de las drogas no parecen estar con la realidad.
Tomemos la nueva droga, Ingrezza (valbenazina) para tratando una enfermedad causada por tomar las drogas comunes utilizados en enfermedades mentales y sus efectos secundarios asociados. La nueva enfermedad es Tardive Dyskinesia. Cuesta a cada paciente de $200 a $400 al día o de $73.000 a $146.000 al año. Hay medio millón de enfermos de TD en los Estados Unidos. Si sólo la mitad de ellos (250.000) fueron tratado con esta droga, le daría a su fabricante hasta $3.650 millones. Esta cantidad no es mucho menor que los $10.700 millones de las ventas de Eli Lilly & Company en el primer medio año de 2019, según lo informado para este año en C&EN, 12 de agosto de 2019, pág. 13. Aun así, sus ventas anuales serían sólo $21.400 millones. Mientras que Ingrezza por sí misma obtiene 1/6 equivalente a las ventas anuales de Eli Lilly. ¿Qué pasa con el resto? ¿Pueda alguien económicamente inteligente nos explicar a los científicos simples porqué las ventas de drogas se reportan en miles millones pero rara vez, si es que alguna vez, en miles de ‘billiones’ (o ‘trillions’) donde parecen más propensos a pertenecer? hashtag#Ingrezza hashtag#valbenazina hashtag#Tardivedyskinesia hashtag#enfermedades hashtag#costos hashtag#Elililly hashtag#mentales hashtag#billiones hashtag#miles hashtag#millones
The costs of drugs don’t seem to gibe with reality.
Or is it just me who has a problem dealing with big numbers? As an example, let’s take the new drug, Ingrezza (valbenazine), for treating a manmade disease caused by taking common medications used in mental illnesses and their associated side effects. The new disease is Tardive Dyskinesia. It costs each patient $200 to $400 a day or $73,000 to $146,000 a year! There are half a million TD sufferers in the United States. If only half of them (250,000) were treated with this drug, it would afford its manufacturer up to $3.65 billion. This amount is not much lower than the $10.7 billion of Eli Lilly & Company’s sales in the first half year of 2019 for all of its drugs, as reported in C&EN, August 12, 2019, p. 13. Still, its annual sales would be only about $22 billion. While Ingrezza by itself gets 1/6 equivalent of Eli Lilly’s annual sales. Where is the rest hidden? Would someone economically intelligent explain to us plain scientists why drug sales are reported at only $billions but rarely, if ever, in $trillions, where they seem most likely to belong? hashtag#drughashtag#costshashtag#manmadehashtag#newdiseasehashtag#Ingrezzahashtag#mentalillnesseshashtag#drugcausedhashtag#valbenazinehashtag#Elilillyhashtag#tardivedyskinesia $trillionsvsbillions
Después de haber pasado décadas investigando productos químicos y hierbas, incluyendo análogos de psilocibina, tengo serias preocupaciones sobre cómo serán tratados en caso de que se conviertan en terapias.
Consideramos un producto químico natural y su versión sintética idéntica siempre que ambos tengan la misma estructura química y sean puros. Pero, ¿qué tan puro? Realistamente, con incluso 2% impurezas, un producto químico hecho por síntesis y uno aislado de hierbas, puede tener conjuntos totalmente diferentes de sustancias químicas desconocidas, potencialmente tóxicas. Los presentes en la versión sintética son más probables tóxicos, petroquímicos no comestibles, mientras que los presentes en la versión natural son de la misma fuente natural, hierba o alimento. Durante la purificación, se supone que estas impurezas deben ser eliminadas, pero no lo son. Por lo tanto, después de más de 80 años de perseguir la terapia de drogas con sintéticos, hemos creado el ciclo vicioso. A la luz de la mentalidad actual de fiebre de oro en este campo, no cometamos el mismo error con setas psilocibina, baeocistina, y norbaeocistina como hemos con suplementos herbarios. hashtag#psilocybinahashtag#análogoshashtag#baeocistinahashtag#norbaeocistinahashtag#cicloviciosohashtag#naturalhashtag#sintéticahashtag#tóxicoshashtag#petroquímicahashtag#setas