Month: December 2019

Look what profit-oriented drug therapy has done to our country – its well-established vicious cycle only benefits drug-makers and their associates.

             Our precious health should not be traded or sold at will.  If it is turned into a business, it should be either non-profit or consumer(patient)-owned.  Otherwise, it should be run by our government after its REAL ‘swarm’ has been drained.   

             The whole healthcare system, esp., drug therapy, has to be revamped.  I believe our younger generations with their increasingly non-drug and true-prevention approach, would start the process.  And to avoid being stuck with the one-sided vicious cycle, they have no choice but to take the non-synthetic route because after 80 years of synthetic exercises without true benefits to our overall health (despite some isolated advances), we need the break back to nature.  We have found it in psilocybin mushrooms!  I will spend the rest of my life to ensure this does not again lead to synthetics as with herbal supplements.  Instead, psilocybin, baeocystin, and norbaeocystin will be produced by fermentation and standardized in situ for research and treatment of major diseases. #healthcare #business #nonprofit #consumer patientowned #government #psilocybin #baeocystin #norbaeocystin #drugtherapy #alternative

Tomemos la nueva droga, Ingrezza (valbenazina) para tratando una enfermedad causada por tomar las drogas comunes utilizados en enfermedades mentales y sus efectos secundarios asociados. La nueva enfermedad es Tardive Dyskinesia. Cuesta a cada paciente de $200 a $400 al día o de $73.000 a $146.000 al año. Hay medio millón de enfermos de TD en los Estados Unidos. Si sólo la mitad de ellos (250.000) fueron tratado con esta droga, le daría a su fabricante hasta $3.650 millones. Esta cantidad no es mucho menor que los $10.700 millones de las ventas de Eli Lilly & Company en el primer medio año de 2019, según lo informado para este año en C&EN, 12 de agosto de 2019, pág. 13. Aun así, sus ventas anuales serían sólo $21.400 millones. Mientras que Ingrezza por sí misma obtiene 1/6 equivalente a las ventas anuales de Eli Lilly. ¿Qué pasa con el resto? ¿Pueda alguien económicamente inteligente nos explicar a los científicos simples porqué las ventas de drogas se reportan en miles millones pero rara vez, si es que alguna vez, en miles de ‘billiones’ (o ‘trillions’) donde parecen más propensos a pertenecer? hashtag#Ingrezza hashtag#valbenazina hashtag#Tardivedyskinesia hashtag#enfermedades hashtag#costos hashtag#Elililly hashtag#mentales hashtag#billiones hashtag#miles hashtag#millones

Or is it just me who has a problem dealing with big numbers? As an example, let’s take the new drug, Ingrezza (valbenazine), for treating a manmade disease caused by taking common medications used in mental illnesses and their associated side effects. The new disease is Tardive Dyskinesia. It costs each patient $200 to $400 a day or $73,000 to $146,000 a year! There are half a million TD sufferers in the United States. If only half of them (250,000) were treated with this drug, it would afford its manufacturer up to $3.65 billion. This amount is not much lower than the $10.7 billion of Eli Lilly & Company’s sales in the first half year of 2019 for all of its drugs, as reported in C&EN, August 12, 2019, p. 13. Still, its annual sales would be only about $22 billion. While Ingrezza by itself gets 1/6 equivalent of Eli Lilly’s annual sales. Where is the rest hidden? Would someone economically intelligent explain to us plain scientists why drug sales are reported at only $billions but rarely, if ever, in $trillions, where they seem most likely to belong? hashtag#drughashtag#costshashtag#manmadehashtag#newdiseasehashtag#Ingrezzahashtag#mentalillnesseshashtag#drugcausedhashtag#valbenazinehashtag#Elilillyhashtag#tardivedyskinesia $trillionsvsbillions

Consideramos un producto químico natural y su versión sintética idéntica siempre que ambos tengan la misma estructura química y sean puros. Pero, ¿qué tan puro? Realistamente, con incluso 2% impurezas, un producto químico hecho por síntesis y uno aislado de hierbas, puede tener conjuntos totalmente diferentes de sustancias químicas desconocidas, potencialmente tóxicas. Los presentes en la versión sintética son más probables tóxicos, petroquímicos no comestibles, mientras que los presentes en la versión natural son de la misma fuente natural, hierba o alimento. Durante la purificación, se supone que estas impurezas deben ser eliminadas, pero no lo son. Por lo tanto, después de más de 80 años de perseguir la terapia de drogas con sintéticos, hemos creado el ciclo vicioso. A la luz de la mentalidad actual de fiebre de oro en este campo, no cometamos el mismo error con setas psilocibina, baeocistina, y norbaeocistina como hemos con suplementos herbarios. hashtag#psilocybinahashtag#análogoshashtag#baeocistinahashtag#norbaeocistinahashtag#cicloviciosohashtag#naturalhashtag#sintéticahashtag#tóxicoshashtag#petroquímicahashtag#setas

We consider a natural chemical and its synthetic version identical provided they both have the same chemical structure and are pure. But how pure? Realistically, with even 2% impurities, a chemical made by synthesis and one isolated from herbs, can have totally different sets of unknown, potentially toxic chemicals. Those present in the synthetic version are most likely toxic, inedible petrochemicals, while those present in the natural version are from the same natural source, herb or food. During purification, these impurities are supposed to be removed, but are not. Hence, after 80 plus years of pursuing drug therapy with synthetics, we have created the vicious cycle. In light of the current gold-rush mentality in this field, let’s not make the same mistake with psilocybin, baeocystin, and norbaeocystin mushrooms as we have with herbal supplements. See the example of levodopa impurities on pp. 94-96 of my latest book, “My Life & Rollercoaster Caeer.” hashtag#psilocybinhashtag#analogshashtag#baeocystinhashtag#norbaeocystinhashtag#viciouscyclehashtag#levodopahashtag#naturalhashtag#synthetichashtag#toxichashtag#petrochemicalshashtag#mushroomshashtag#impuritieshashtag#hempcbd

No tenemos idea de cómo llegó. Pero pensamos que Dios lo creó, o a través de la evolución. A pesar de todo, estamos aquí hoy, buscando “curas” para enfermedades o explorando el espacio exterior. Ambos esfuerzos son sólo una pequeña parte de cada entidad. Al ir a la luna y volver, nuestra salud colectiva no se ha visto significativamente afectada, si es que lo hace. Pero en la terapia de drogas, nuestro cuerpo complejo está íntimamente involucrado. Sin utilizar las ciencias apropiadas para abordar los problemas del tiempo y la complejidad de nuestro cuerpo, hemos desperdiciado gran parte de los últimos 80 años de esfuerzos, que terminaron en el ciclo vicioso. Este ciclo se describe ampliamente en mis libros y publicaciones en línea. Para que la terapia de drogas tenga éxito, estos 2 problemas deben ser abordados, de lo contrario la terapia “basada en evidencia” no es más científica que la medicina herbaria. Ambos son ensayo y error, excepto este último tiene la ventaja del tiempo. Por favor, ver mi artículo “A Disruptive Concept in Drug Therapy” en mi LinkedIn: https://www.linkedin.com/in/albert-leung-9b933913/ o blog: www.ayslcorp.com/blog. hashtag#terapiahashtag#drogashashtag#ensayoyerrorhashtag#cicloviciosohashtag#cienciasapropriadashashtag#tiempohashtag#herbariahashtag#cuerpo

We have no idea how we got it. But we figured God created it, or it got here via evolution. Regardless, we are here today, trying to find ‘cures’ for illnesses or to explore outer space. Both endeavors are only a tiny part of each entity. In going to the moon and back, our collective health has not been significantly affected, if at all. But in drug therapy, our complex body is intimately involved, along with time. Without using the appropriate sciences to address these 2 issues, we have wasted much of the past 80 years’ efforts, with the drugs ending up in the vicious cycle. This vc is described extensively in my books and online posts. Hence, for drug therapy to be safe and effective, these 2 issues must be addressed, otherwise ‘evidence-based’ drug therapy is no more scientific than herbal medicine – both are trial and error, except the latter has the advantage of time, hence safer. For a quick view of why drug therapy is not scientific, with its toxic drugs ending up in the vc, see my article “A Disruptive Concept in Drug Therapy” on my LinkedIn: https://www.linkedin.com/in/albert-leung-9b933913/ or blog: www.ayslcorp.com/blog. hashtag#minicosmoshashtag#nonscientifichashtag#cosmoshashtag#drugtherapyhashtag#complexhashtag#disruptiveconcepthashtag#herbal

I am one who have never taken psychedelics, because I don’t want to lose control of my senses. Since I was plain lucky to have finished college with my uncle & aunt’s support, and was doing graduate studies at U. of Michigan on a teaching assistantship and fellowship, I didn’t want to bring shame to my family for doing something out of character. That was an old Chinese cultural thing. For 5 years, I spent most of my time in the lab culturing Psilocybe baeocystis mycelium and ‘coaxing’ it to produce the highest amounts of 2 new psilocybin analogs. I isolated and identified them, naming them baeocystin and norbaeocystin. That was over 55 yrs ago! And as far as I know, no one has yet mass-produced these compounds. I am ready if you are. The mycelium of P. baeocystis containing specific amounts of psilocybin, baeocystin, and norbaeocystin can be produced by my method using fermentation/biotech. If ingested, the natural mycelium will have the ‘entourage’ effects not found in its synthetic counterparts along with their minute amounts of potentially highly toxic petrochemical byproducts as impurities. hashtag#baeocystinhashtag#norbaeocystinhashtag#psilocybinhashtag#fermentationhashtag#biotechhashtag#myceliumhashtag#psychedelicshashtag#entourageeffectshashtag#syntheticshashtag#toxicimpurities

I don’t personally know Paul, but we have mutual friends, like Dennis McKenna in his documentary, “Fantastic Fungi.” When I went to Michigan for graduate studies in 1962, Paul was only a kid. He couldn’t have witnessed first-hand the psilocybin research in human health yet. As for baeocystin and norbaeocystin, I have first-hand knowledge of them because I am the scientist who first isolated them as new compounds from Psilocybe baeocystis in liquid culture, determining their chemical structures, and giving them appropriate names. However, these findings were not published by my thesis advisor, Ara G. Paul, and me until 1967-1968 in 2 papers. Although Varro E. (Tip) Tyler was Ara’s close friend leading another group in Psilocybe research in Washington, we did our work independently. I don’t know how Paul got his information about baeocystin being toxic, or that Benedict, Tip, and I together named the chemicals. Does anyone know where this information on baeocystin being toxic came from, before I even determined its chemical structure? hashtag#baeocystinhashtag#norbaeocystinhashtag#Joeroganhashtag#podcast1385hashtag#paulstametshashtag#psilocybinhashtag#toxichashtag#firsthandhashtag#liquidculturehashtag#Michiganhashtag#Washingtonhashtag#chemicalstructure

Besides this podcast, I also recommend Paul’s documentary, “Fantastic Fungi.” Great piece of work! Take your children to see it. It’ll introduce them to the fantastic world of mushrooms, molds, mycelia, etc., so far still mostly unnoticed. But it will be a part of their future world providing them with solutions to many of their health and environmental problems. In my opinion, the next real breakthrough in medicine will again come from fungi, since penicillin. But this time, the elements involved would not be just one natural chemical, to be followed by endless synthetics. After over 80 years of searching for ‘cures’ for diseases and found none, some of us dedicated scientists are once again alerted to more old clues. They are leading us to new natural remedies among those that are already here waiting to be discovered since we appeared on this planet. They won’t include totally brand-new, unknown synthetic chemicals that are in the vicious cycle. Please see my next post for more details on psilocybin analogs. hashtag#JoeRoganhashtag#PaulStametshashtag#mushroomhashtag#fantasticfungihashtag#childrenhashtag#environmentalhashtag#breakthroughhashtag#fungihashtag#penicillinhashtag#naturalchemicalshashtag#syntheticshashtag#remedieshashtag#viciouscyclehashtag#psilocybinhashtag#moldhashtag#mycelia